The average reduction of RNFL thickness was inversely associated with the decrease of central cingulate cortex volume after the adjustment of age and total intracranial volume ( β = −0.41, P = 0.039). Among them, 28 participants completed the follow-up assessments. Results: Fifty old participants were screened and 40 participants (mean age 71.8 ± 3.9 years, 60% were male) were enrolled at baseline. Associations among the changes of RNFL, brain structures and cognitive function were analyzed with Spearman correlation and multiple linear regression models adjusting for the confounding factors. Cognitive function was assessed using the Chinese version of Mini-Mental State Examination (CMMSE) and Repeatable Battery for the Assessment of Neurological Status. Materials and Methods: We measured the RNFL thickness using optical coherence tomography (OCT) and brain structure volumes by 3T magnetic resonance imaging (MRI) before and after 12 months. We, therefore, set out a prospective investigation to determine the association between longitudinal changes of RNFL thickness and brain atrophy in nondemented older participants over a period of 12 months. However, whether the changes in RNFL thickness are associated with the atrophy of brain structure volumes remains unknown. 4Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, Chinaīackgrounds: Abnormal retinal nerve fiber layer (RNFL) thickness has been observed in patients with Alzheimer’s disease (AD) and therefore suggested to be a potential biomarker of AD.3Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.2Anesthesia and Brain Research Institute, Tongji University School of Medicine, Shanghai, China.1Department of Psychiatry, Shanghai 10th People’s Hospital, Tongji University, Shanghai, China.Zhongyong Shi 1,2 Hailin Zheng 1,2 Jingxiao Hu 1,2 Lijuan Jiang 3 Xinyi Cao 3 Yupeng Chen 1,2 Xinchun Mei 1,2 Chunbo Li 3,4 Yuan Shen 1,2*
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